Catecholamines and the carcinoid syndrome

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The Carcinoid Syndrome

THE first description of a carcinoid tumour was as early as 1888 (Lubarsch). Later attention was drawn to the possibility that the cells of these tumours (known as argentaffinomas) act as secretors of some "endocrine" substance. "Enteramine" or "serotonin" (5 hydroxytryptamine or 5 H.T.) was later isolated from carcinoid tumours and recently its degradation product-5 hydroxy-indoleacetic acid o...

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Controlling the carcinoid syndrome.

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Anesthesia for the carcinoid syndrome.

The first report of an association between a carcinoid tumor and a specific syndrome was reported by Biorck and associates in 1952. 6 Since that time, literature on the carcinoid syndrome has appeared more frequently. In 1976, Mason and Steane published two review articles on the subject which have served as reference guides for anesthesia personnel.6' 7 Fewer than 50 cases of the carcinoid syn...

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Case of the month #166: carcinoid heart disease. Carcinoid syndrome.

A previously healthy 60-year-old woman presented with a 3-week history of fatigue and exertional dyspnea. Over the past year, she had experienced episodic wheezing, facial flushing, diarrhoea, and an unintentional 40-lb weight loss. On physical examination, she demonstrated venous telangiectasia in the malar region, mild peripheral cyanosis, and an elevated jugular venous pressure with a domina...

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Somatostatin, gastrointestinal peptides, and the carcinoid syndrome.

During a control infusion noradrenaline and alcohol each provoked carcinoid flushing in four of five patients and pentagastrin in two of five patients. When tetradecapeptide somatostatin was infused on another day no patient flushed at any time, even when 16 microgram of either noradrenaline or pentagastrin were administered. Carcinoid flushing was not associated with release of gastrin or any ...

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ژورنال

عنوان ژورنال: Anaesthesia

سال: 2007

ISSN: 0003-2409,1365-2044

DOI: 10.1111/j.1365-2044.1993.tb06809.x